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Doxepin hydrochloride is a tricyclic antidepressant that is dibenzoxepin-derivative. TCAs are like phenothiazines. They have a ring system using an amine substituent on the ring. In people, doxepin doesn’t have an effect on mood or stimulation, but might cause sedation. In people that are depressed, doxepin exerts a positive impact on mood. TCAs are powerful inhibitors of norepinephrine and dopamine reuptake. Tertiary amine TCAs, such as amitriptyline and doxepin, are inhibitors of serotonin reuptake such as desipramine and nortriptyline.
TCAs also cortical receptors and sensitize receptors with use. The effects of TCAs are regarded as because of an increase in serotonergic neurotransmission. TCAs block adrenergic receptors, histamine receptors and muscarinic receptors, which accounts for their hypotensive, sedative and anticholinergic effects. Doxepin has effects than amitriptyline.
See toxicity segment below. Doxepin could be used to deal with sleeplessness and depression. Indications consist of nervousness, and pain. Doxepin may be used as a second line agent to treat urticaria.
Side Effects
- Common side effects of doxepin include sleepiness, nausea and upset stomach.
- Common side effects of doxepin cream include burning or stinging at site of application, dry mouth, and drowsiness.
Toxity
LD50=26 (mg/kg) (in mice(Fig); LD50=16 (mg/kg) (in rats(Fig); Cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity.
Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, diminished memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression.
Withdrawal symptoms include gastrointestinal disturbances, nervousness, and sleeplessness.
Doxepin Interactions
Inform your doctor about all the medications you take including prescription and nonprescription medications, vitamins, and herbal nutritional supplements.
Doxepin and other drugs may affect each other causing unwanted effects. Doxepin might influence the way other medicines work, along with other drugs could affects how doxepin functions. Especially tell your health care provider if you choose:
- a monoamine oxidase inhibitor (MAOI).
- Cimetidine (Tagamet) or even alternative drugs that may affect certain liver enzymes
- particular allergy drugs (antihistamines) along with other drugs that may cause you to be sleepy or influence your breathing
- the diabetes medication tolazamide
Consult your physician or pharmacist if you aren’t positive whether your medication is one which is listed previously.
Know the medicines you require. Maintain a record of your medicines together with you to demonstrate your physician and pharmacist every time you receive a new medication.