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Estradiol is a form of estrogen, a female sex hormone. Estrogen is essential for many processes within the human body. Estradiol is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include replacement of estrogen, and prevention of osteoporosis in postmenopausal women in women with ovarian failure or other ailments which cause a scarcity of testosterone in the human body.
Estradiol is used in men and women as part of cancer therapy. Estradiol may also be used for purposes.
Side Effects
- redness or irritation of the skin that was covered by the estradiol patch, cream, or gel
- anxiety
- changes in mood
- constipation
- heartburn
- nausea
- hair loss
- unwanted hair growth
- painful menstrual periods
- runny nose or congestion
- cough
- difficulty wearing contact lenses
- headache
- vomiting
- breast pain or tenderness
- swelling, redness, burning, irritation or itching of the vagina
- gas
- vaginal discharge
- depression
- darkening of skin on face (may not go away even after you stop using transdermal estradiol)
- back, neck, or muscle pain
- change in sexual desire
- weight gain or loss
Toxity
Can cause nausea and vomiting, and withdrawal bleeding may occur in females.
Estradiol Interactions
Inform your doctor about all the medications that you take, including non-prescription and prescription drugs, vitamins, and herbal nutritional supplements. Especially tell your health care provider if you choose:
- Amiodarone (Cordarone, Pacerone)
- Antifungals like itraconazole (Sporanox) and ketoconazole (Nizoral)
- Aprepitant (Emend)
- Carbamazepine (Carbatrol, Epitol, Tegretol)
- Cimetidine (Tagamet)
- Clarithromycin (Biaxin)
- Cyclosporine (Neoral, Sandimmune)
- Dexamethasone (Decadron, Dexpak)
- Diltiazem (Cardizem, Dilacor, Tiazac, others)
- Erythromycin (E.E.S, Erythrocin)
- Fluoxetine (Prozac, Sarafem)
- Fluvoxamine (Luvox)
- Griseofulvin (Fulvicin, Grifulvin, Gris-PEG)
- Lovastatin (Altocor, Mevacor)
- Drugs for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) like atazanavir (Reyataz), delaviridine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), lopinavir (in Kaletra),nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase)
- Medicines for thyroid disorder
- Nefazodone
- Other drugs that contain estrogen
- Phenobarbital
- Phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin)
- Rifampin (Rifadin, Rimactane, at Rifamate)
- Sertraline (Zoloft)
- Troleandomycin (TAO)
- Verapamil (Calan, Covera, Isoptin, Verelan)
- Zafirlukast (Accolate)
- St. John’s Wort
This isn’t an entire collection of all estradiol drug interactions. Consult your health care provider or pharmacist to learn more.