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Prescription aspirin is traditionally used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Additionally it is used to ease mild to moderate pain, including menstrual pain (pain that occurs before or during a menstrual period). Nonprescription aspirin can be used to decrease fever and to relieve minor aches and pain from toothaches, muscular aches, arthritis, and menstrual cycle, the frequent cold, headaches, and backaches.
Ibuprofen is in a class of medications. It works by stopping the body’s creation of a substance that causes fever, pain, and inflammation.
Side Effects
- fluid retention
- gastrointestinal upset, including pain, bloating, constipation, diarrhea, heartburn, gas, nausea, and vomiting
- nervousness
- ringing in the ears
- headache
- rash
- itching
Toxity
Side effects: May cause peripheral edema and fluid retention. Use caution in patients with congestive heart failure or severe uncontrolled hypertension. May cause dyspepsia, heartburn, nausea, vomiting, anorexia, diarrhea, nausea, stomatitis, flatulence, bloating, epigastric pain, and stomach pain. Peptic ulcer and GI bleeding are reported. May also cause nausea, headache and anxiety. Acute renal failure accompanied by severe tubular necrosis was reported.
Most frequent signs of overdose are stomach pain, nausea, vomiting, lethargy, vertigo, drowsiness (somnolence), dizziness and insomnia. Other signs of overdose include headache, loss of awareness, tinnitus, CNS depression, convulsions and seizures. May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (mostly in very young pediatric patients).
LD50=1255mg/kg(orally in mice)
Ibuprofen Interactions
Inform your doctor about all the medications that you take, including non-prescription and prescription drugs, vitamins, and herbal nutritional supplements. Especially tell your health care provider if you choose:
- Anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven)
- aspirin
- other NSAIDs like ketoprofen (Orudis KT, Actron) and naproxen (Aleve, Naprosyn)
- oral steroids like dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone)
- angiotensin-converting enzyme (ACE) inhibitors like benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik)
- diuretics (‘water pills’)
- lithium (Eskalith, Lithobid)
- methotrexate (Rheumatrex)
This isn’t an entire collection of ibuprofen drug connections. Consult your health care provider or pharmacist to learn more.