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Atapryl, Carbex, Eldepryl, Emsam, Zelapar
Selegiline is used to help control the symptoms of Parkinson’s disease (PD; a disease of the nervous system which causes problems with movement, muscle control, and equilibrium) in individuals that are taking levodopa and carbidopa combination (Sinemet). Selegiline can help people by preventing the consequences of levodopa/carbidopa from consuming between doses, lowering the dose of levodopa/carbidopa required to control symptoms, and increasing the period of time which levodopa/carbidopa will continue to control symptoms.
Selegiline is in several drugs called monoamine oxidase type B (MAO-B) inhibitors. It works by boosting the quantity of dopamine (a pure substance that’s required to restrain motion) from the mind.
Side Effects
- Selegiline may worsen your depression, give you suicidal thoughts, or cause unusual changes in behavior. Call your doctor right away if you feel worse with selegiline.
- Selegiline can cause a sudden, large increase in blood pressure (‘‘hypertensive crisis’’) if you eat certain foods and drinks during treatment. See “Drug Precautions”. A hypertensive crisis can lead to stroke and death. Symptoms of a hypertensive crisis include the sudden onset of severe headache, nausea, stiff neck, a fast heartbeat or a change in the way your heart beats (palpitations), a lot of sweating, and confusion. If you suddenly have these symptoms, get medical care right away.
- Selegiline can cause serious and potentially life-threatening reactions if used with certain other medicines. See “Selegiline Drug Precautions”.
- Selegiline can cause low blood pressure. Lie down if you feel dizzy, faint, or lightheaded. Change your position slowly if low blood pressure is a problem for you. Tell your doctor if you have these symptoms. You may need a lower dose of selegiline.
- Selegiline may cause a mental condition called mania or hypomania (mental condition which causes high moods) in people who have a history of mania.
Toxity
LD50=63 mg/kg (rats, IV)
Selegiline Interactions
Selegiline may cause severe and possibly life-threatening reactions when used with some other drugs. Don’t take the next drugs when utilizing selegiline, and for 2 weeks after discontinuing selegiline:
- Other drugs to treat depression (antidepressants), for example other MAOI drugs
- medicine that comprises selegiline (for instance, Eldepryl)
- St. John’s wort (a herbal nutritional supplement)
- Demerol (meperidine), or medications that include meperidine (some narcotic pain medication) along with the pain drugs tramadol, methadone, or propoxyphene
- Tegretol (carbamazepine), or even other drugs that include carbamazepine (also a seizure medication)
- Trileptal (oxcarbazepine), or other drugs that include oxcarbazepine (some seizure medication)
- Cold or influenza preparations which include dextromethorphan
- Flexeril or alternative drugs that include cyclobenzaprine (a medication used to treat muscle spasms)
- decongestant drugs, located in several products to deal with cold symptoms
- over-the-counter diet pills or herbal weight reduction goods
- any herbal or dietary supplement which comprises tyramine
- medicines known as amphetamines, also known as stimulants or \”uppers\”
- BuSpar (buspirone), an anxiety medication
Some of these medications might need to be discontinued at least a week before you’re able to begin using selegiline. Make sure you inform your physician about all the medications you take including non-prescription and prescription drugs, vitamins, and herbal nutritional supplements.
This isn’t an entire collection of all selegiline drug interactions. Consult your health care provider or pharmacist to learn more.