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Simvastatin is used jointly with diet and exercise also to reduce the possibility that heart operation is going to be needed or who are at risk of cardiovascular disease and also to decrease the chance of heart attack and stroke. Simvastatin can also be used to lower the quantity of fatty substances like low-density lipoprotein (LDL) cholesterol (“bad cholesterol”) and triglycerides from the blood and also to improve the quantity of high-density lipoprotein (HDL) cholesterol (“good cholesterol”) in the bloodstream.
Simvastatin may also be used to lower the total amount of cholesterol and other fatty substances in the blood in children and teens 10 to 17 decades old who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol can’t be taken out of the body normally). Simvastatin is in a class of drugs called HMG-CoA reductase inhibitors (statins).
It works by slowing the production of cholesterol within the body to lower the quantity of cholesterol which block blood flow and may develop on the walls of their arteries.
Accumulation of cholesterol and fats along the walls of your arteries (a process called atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of the body. Lowering your blood level of fats and cholesterol with simvastatin was proven to reduce cardiovascular disease, angina (chest pain), strokes, and heart ailments.
Side Effects
- headache
- nausea
- stomach pain
- constipation
- upper airway infections
- muscle and joint aches
Toxity
The most frequent adverse reactions that cause discontinuation of treatment include gastrointestinal ailments (0.5 percent), myalgia (0.1 percent), and arthralgia (0.1 percent).
Simvastatin Interactions
Inform your doctor about all the medications that you take, including non-prescription and prescription drugs, vitamins, and herbal nutritional supplements. Especially tell your health care provider if you choose:
- Warfarin (Coumadin, Jantoven)
- cyclosporine (Neoral, Sandimmune)
- danazol (Danocrine)
- amiodarone (Cordarone, Pacerone)
- ranolazine (Ranexa)
- colchicine (Colcrys)
- digoxin (Lanoxin)
- calcium channel blockers like nifedipine (Adalat, Nifedical, Procardia), amlodipine (Norvasc), verapamil (Calan, Isoptin, Covera, Verelan), and diltiazem (Cardizem)
- drugs that prevent the enzyme CYP3A4 like several macrolide antibiotics (clarithromycin, telithromycin), and a few HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir), even a few HCV protease inhibitors (boceprevir, telaprevir), a few azole antifungals (ketoconazole, itraconazole, posaconazole, voriconazole), conivaptan (Vaprisol), delavirdine (Rescriptor), and nefazodone (Serzone)
- drugs that prevent the enzyme CYP2D6 like quinidine (Qualaquin), fluoxetine (Prozac,Sarafem), amitriptyline (Elavil, Amitril), and paroxetine (Paxil)
- fibrates like gemfibrozil (Lopid) or fenofibrate (TriCor)
- nicotinic acid drugs like niacin (Niacor, Niaspan, Slo-NiacinC along with vitamin B3
This isn’t an entire collection of all simvastatin drug interactions. Consult your physician or pharmacist to learn more.